Therapeutic Potential of Monoamine Transporter Substrates
نویسندگان
چکیده
منابع مشابه
The Vesicular Monoamine Transporter
The vesicular monoamine transporter (VMAT) is a membrane-embedded protein that transports monoamine neurotransmitter molecules into intraneuronal storage vesicles to allow subsequent release into the synapse.1,2 By accumulating both newly synthesized neurotransmitter molecules and freshly returned neurotransmitter molecules from the synapse, VMAT function plays a critical role in the signaling ...
متن کاملProbing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling
The structurally similar serotonin and dopamine transporter (resp. SERT and DAT) play an important role in neuronal transmission. Although the concept of their function, i.e. the re-uptake of neurotransmitters from the synaptic cleft, has been extensively studied, the exact mechanism for their substrate selectivity is still unknown. Phenylethylamines (PEAs) are ligands of SERT and DAT and many ...
متن کاملSelective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3.
The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogenic amines. Using the Flp-in system, we expressed human PMAT (hPMAT) and human OCT3 (hOCT3) at similar levels in human embryonic kidney 293 cells. Parallel and detailed kinetics analysis revealed distin...
متن کاملSelective substrates for non-neuronal monoamine transporters.
The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters. In the present study, selective transport substrates were identified that allow, by analogy to receptor agonists, functional ...
متن کاملMonoamine transporter pharmacology and mutant mice.
Monoamine transporters, such as the dopamine transporter, 5-HT transporter and noradrenaline transporter, in the plasma membrane provide effective control over the intensity of monoamine-mediated signaling by recapturing neurotransmitters released by presynaptic neurons. These proteins represent established targets for several psychotropic drugs, including psychostimulants and antidepressants; ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Topics in Medicinal Chemistry
سال: 2006
ISSN: 1568-0266
DOI: 10.2174/156802606778249766